Background:
The Hedgehog Signaling Pathway plays an essential role in embryonic development and is involved in the fate of stem cells and in the etiology of human disease. Mutations in hedgehog signaling during embryonic development can lead to severe developmental abnormalities. The birth defect, holoprosencephaly, results from the failure of the embryonic prosencephalon to divide to form cerebral hemispheres. Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, breast, pancreas, prostate, digestive tract and skin. Therefore, an opportunity exists to develop compounds with unique mechanisms of action.
Applications:
- High quality platofrm for small molecule drug screenign to identify activators or antagonists for potential therapeutics
- Diagnostic imaging in live cells
- Bioimaging
State of Development:
For further information, a confidentiality agreement can be provided. Publication pending review and USPTO patent application pending.
Contact:
Diane L. Borghoff, B.S., M.S.
Marketing & Licensing Associate – Intellectual Property
Health Research, Inc. - 150 Broadway – Suite 560
Menands, New York 12204-2719 U.S.A.
Phone 518-431-1213 Fax 518-431-1234
E-mail: DLB22@healthresearch.org Website: www.healthresearch.org
