With the launch of the new Human Subjects System (HSS), there is now a new two-step submission process for any Research Performance Progress Reports (RPPR) reporting inclusion enrollment updates.  When investigators are completing their RPPR inclusion enrollment updates, the system will now automatically open a separate screen for enrollment data entry.  This requires separate submission steps for the enrollment data file and the full RPPR file.
The NIH RPPR Instruction Guide has not yet been updated regarding this new process.  In the meantime, please see https://era.nih.gov/node/522 for additional details and instructions for Signing Officials and Principal Investigators.