Spinal Cord Reflex Neurorehabilitation Training and Device

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Initial human studies of the H-Reflex Device have shown significant improvements in locomotion in spinal cord-injured (SCI) patients. Presented here is the use of a device and protocol to improve locomotor function in people with SCI by down-conditioning hyperactive reflexes or, if appropriate, up-conditioning hypoactive reflexes.  Using operant conditioning of spinal reflexes, we can target plasticity to specific reflex pathways, which results in significant improvements in walking performance.  These include less spasticity, easier stepping, increased walking speed, improved gait symmetry and decreased dependence on assistive devices.

The device consists of hardware and software that can administer the protocols in physical therapy sessions without the direct involvement of an expert.  The hardware consists of a nerve stimulation-EMG (electromyographic) recording (NS-EMG) component that can be mounted at a given place on the body (e.g., calf and knee) and a programmable controller with monitor that communicate via telemetry.  The H-Reflex Device modifies specific nervous system pathways through use of an operant conditioning protocol. Detailed studies in laboratory animals have revealed the anatomical and physiological nature of these spinal cord changes.

In the News

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Current neurological rehabilitation methods consist primarily of the repeated practice of motor and cognitive skills (i.e. treadmill locomotion, reach and grasp actions, etc.).  Although this strategy is logical and often beneficial, it is seldom fully effective.  These skills depend on plasticity (i.e., changes) throughout the CNS from the cortex to the spinal cord.  By providing the ability to target change to specific reflex pathways, reflex conditioning methods can guide plasticity to achieve widespread effects on the complex nervous system networks that produce neuromuscular skills, and thereby improve these skills beyond the levels possible with conventional practice.

The spinal stretch reflex (SSR), also called the tendon jerk reflex or M1, is the initial response to sudden muscle stretch; this reflex excites the muscle that opposes the sudden stretch.  The electrical analog of the SSR, the H(i.e., Hoffman)-reflex, is elicited by weak electrical stimulation of the peripheral nerve, rather than by muscle stretch.  Both the SSR and H-reflex are produced mainly by a two-neuron, monosynaptic pathway that synapses in the spinal cord.

People with incomplete spinal cord injury (SCI) frequently suffer motor disabilities due to spasticity and poor muscle control, even after conventional therapy.  Abnormal spinal reflex activity often contributes to these problems.   In people with SCI, modulation of the soleus H-reflex across the step cycle is absent or diminished greatly and the abnormality affects locomotor EMG activity, contributing to spasticity (e.g., clonus), foot drop and other disabling problems.   Because they can target particular spinal pathways by either weakening or strengthening the activity of these pathways, reflex-conditioning protocols can be designed to focus on each individual’s particular deficits.

Applications

  • Five major groups of people directly benefit – Spinal Cord Injuries, Stroke, Cerebral Palsy, Multiple Sclerosis and Peripheral Nerve Injuries
  • Supplementation of conventional rehabilitation – Neurologists, Physiatrists, Physical Therapists and Occupational Therapists can already prescribe patient locomotion therapies; this new highly specific therapy, which can target each individual’s particular impairment, could easily be added to an already existing set of conventional therapies.
  • Rehabilitation neurophysiology research

Advantages

  • Can improve locomotion resulting in faster walking, greater distance traversed, easier stepping, better foot placement, reduced spasticity/clonus, reduced foot drop, improved balance, and decreased use of assistive devices.
  • Better quality of life by enabling autonomy
  • Personalized treatment targeting individual deficits
  • Does not require extensive staff or patient training
  • In the future, it may be used by a patient at home with only periodic Internet-based oversight from a therapist.

State of Development

Middle research stage – Prototype available – USPTO #8,862,236;  #9,138,579;  #9,545,515

Publications

*** Thompson, AK, Pomerantz, FR, and Wolpaw, JR. “Operant Conditioning of a Spinal Reflex Can Improve Locomotion after Spinal Cord Injury in Humans.” J Neurosci, 2013 Feb 6,  33(6):2365-2375. Doi: 10.1523/JNEUROSCI 3968-12.2013.

Thompson, AK., and Wolpaw, JR. “The Simplest Motor Skill:  Mechanisms and Applications of Reflex Operant Conditioning.” Exerc Sport Sci Rev 2014 Feb 13

Thompson, AK and Wolpaw, JR. “Operant Conditioning of Spinal Reflexes: From Basic Science to Clinical Therapy”.   Front Integr Neurosci 2014 Mar 18; 8:25. Doi: 10.3389/fnint.2014.00025

Thompson, AK and Wolpaw, JR.  “Restoring Walking after Spinal Cord Injury:  Operant Conditioning of Spinal Reflexes Can Help.”  The Neuroscientist 2014. Doi: 10.1177/1073858414527541

Chen Y, Chen L, Liu R, Wang Y, Chen XY, Wolpaw, JR. “Locomotor Impact of Beneficial or Non-Beneficial H-Reflex Conditioning After Spinal Cord Injury.” J Neurophysiol. 2013 Dec 26.

Thompson AK, Chen XY, Wolpaw JR. “Soleus H-Reflex Operant Conditioning Changes the H-Reflex Recruitment Curve.” Muscle Nerve, 2013 Apr; 47(4):539-44. Doi:10.1002/mus.23620.

Contact

Robert L. Gallo
Director, Intellectual Property & Licensing
Health Research, Inc. – 150 Broadway – Suite 560, Menands, New York 12204-2719 U.S.A.
Phone 518-431-1208 Fax 518-431-1234
E-mail: robert.gallo@healthresearch.org Website: www@healthresearch.org